Amygdalin as a Potential Anti-Cancer Agent: A Concise Review of Therapeutic Insights and Mechanisms

Raghad F. Al-Ansari; Khalid Zainualbdeen; Maryam Hamed Jabir; Emad Yousif; Nany Hairunisa; Husnun Amalia

doi:10.47419/bjbabs.v5i4.326

Authors

Raghad F. Al-Ansari Department of Chemistry, College of Science, University of Al-Nahrain, Baghdad, Iraq https://orcid.org/0000-0001-8640-6201
Khalid Zainualbdeen Department of Chemistry, College of Science, Al-Nahrain University, Baghdad,Iraq https://orcid.org/0000-0003-3829-5783
Maryam Hamed Jabir Department of Chemistry, College of Science, University of Al-Nahrain, Baghdad ,Iraq https://orcid.org/0009-0003-4142-6112
Emad Yousif Department of Chemistry, College of Science, University of Al-Nahrain,Baghdad, Iraq, https://orcid.org/0000-0003-1458-4724
Nany Hairunisa Department of Occupational Medicine, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia https://orcid.org/0000-0003-2414-9224
Husnun Amalia Department of Ophthalmology, Faculty of Medicine, Universitas Trisakti, Jakarta, Indonesia https://orcid.org/0000-0001-9727-8874

DOI:

https://doi.org/10.47419/bjbabs.v5i4.326

Keywords:

Laetrile, anti-cancer, medical, treatment, Amygdaline

Abstract

Amygdalin, also known as laetrile, has generated significant controversy within the scientific medical community regarding its efficacy as a cancer treatment. Extracted primarily from the seeds of fruits like apricots and almonds, it has been promoted by certain groups as a potential cure for cancer despite criticism regarding its toxicity and minimal therapeutic value. This review aims to analyze the available literature on amygdalin, focusing on its chemical characteristics, proposed mechanisms of action, and its role in cancer prevention and therapy. A comprehensive review of preclinical data and clinical trials was conducted to assess amygdalin's potential effects and associated risks. The analysis of existing studies provides insights into the complexity of amygdalin's biological activity, including its interactions and suggested pathways in cancer treatment, while highlighting the need for further research to clarify its efficacy and safety. Ultimately, the review contributes to the ongoing discussion surrounding amygdalin's position in oncology and emphasizes the necessity for continued exploration to develop effective cancer treatment strategies.

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References

Thanaa, A., El-Masry., Nora, H., Al-Shaalan., Ehab, Tousson., Manal, Buabeid., Areej, Al-Ghadeer. (2020). Potential therapy of vitamin B17 against Ehrlich solid tumor induced changes in Interferon gamma, Nuclear factor kappa B, DNA fragmentation, p53, Bcl2, survivin, VEGF and TNF-α Expressions in mice. Pakistan Journal of Pharmaceutical Sciences.

M. Enculescu. (2009). Vitamin B17/Laetrile/Amygdalin (a review). Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Animal Science and Biotechnologies. doi: 10.15835/BUASVMCN-ASB:66:1-2:3316.

A.E., Goodridge., Bethany, Sibbitt., John, J., Haluschak., Sateesh, K., Kathula., Aleda, M.H., Chen. (2023). Safety and efficacy of vitamin B in cancer treatments: A systematic review. Journal of Oncology Pharmacy Practice, doi: 10.1177/10781552231178686.

Lucie, Cahlíková., Kateřina, Macáková., Nina, Benešová., Jakub, Chlebek., Anna, Hošťálková., Lubomír, Opletal. (2014). Natural Compounds (Small Molecules) as Potential and Real Drugs of Alzheimer's Disease: A Critical Review. Studies in natural products chemistry, doi: 10.1016/B978-0-444-63281-4.00006-9.

Jincong, Q, Freeman., Jori, Sheade., Fangyuan, Zhao., Olufunmilayo, I., Olopade., Rita, Nanda., Dezheng, Huo. (2023). Demographic and Clinical Characteristics Associated With Familiarity, Interest, and Use of Integrative Therapies Among Patients With Breast Cancer. Integrative Cancer Therapies, doi: 10.1177/15347354231185122.

Ashraf, Barakat, Said., Saleh, Yousef., Ibrahim, A., Ibrahim., Yasmina, K., Mahmoud., Marwa, A., El-Beltagy. (2021). Biochemical Evaluation of Antitumor Activity of Vitamin B17 Alone or in Combination with Platinum Based Drugs Against Ehrlich Ascites Carcinoma in Female Rats. doi: 10.21608/SCVMJ.2021.184983.

https://www.quora.com/Is-amygdalin-B17-beneficial-against-cancer

Ali El Desouky, M. (2022). The Postulated Mechanism of Action of Amygdalin (Vitamin B17) on Cancer Cells. Anti-cancer Agents in Medicinal Chemistry.

doi:(Amir, Aamir Jalal et al. 2009)

Al‐Isawi, J., & Abass, E. (2023). Amygdalin as Anti-Cancer Agent. Journal of Madenat Alelem University College, 15(2), 16-24. https://journal.mauc.edu.iq/index.php/JMAUC/article/view/497

Moertel, C. G., Fleming, T. R., Rubin, J., Kvols, L. K., Sarna, G., Koch, R., ... & Davignon, J. P. (1982). A clinical trial of amygdalin (Laetrile) in the treatment of human cancer. New England Journal of Medicine, 306(4), 201-206. doi: 10.1056/NEJM198201283060403

Barakat, H., Aljutaily, T., Almujaydil, M. S., Algheshairy, R. M., Alhomaid, R. M., Almutairi, A. S., ... & Abdellatif, A. A. (2022). Amygdalin: a review on its characteristics, antioxidant potential, gastrointestinal microbiota intervention, anticancer therapeutic and mechanisms, toxicity, and encapsulation. Biomolecules, 12(10), 1514. doi.org/10.3390/biom12101514

Cipollone, R., Ascenzi, P., Tomao, P., Imperi, F., & Visca, P. (2008). Enzymatic detoxification of cyanide: clues from Pseudomonas aeruginosa Rhodanese. Journal of molecular microbiology and biotechnology, 15(2-3), 199-211. doi.org/10.1159/000121331

Krebs, E.T. (1970). nitrilosides (vitamin B-17), their nature, occurrence and metabolic significance antineoplastics vitamin B-17.

Sashidhar, R. B., Ramakrishna, Y., & Bhat, R. V. (1991). Pellagra, mycotoxins and tryptophan-niacin metabolism. In Kynurenine and Serotonin Pathways: Progress in Tryptophan Research (pp. 631-636). Boston, MA: Springer New York.

Hill II GJ, Shine TE, Hill HZ, Miller C. Failure of amygdalin to arrest B16 melanoma and BW5147 AKR leukemia. Cancer Res. 1976; 36(6):2102-7.

Juengel E, Afschar M, Makarević J, Rutz J, Tsaur I, Mani J, et al. Amygdalin blocks the in vitro adhesion and invasion of renal cell carcinoma cells by an integrin-dependent mechanism. Int J Mol Med. 2016; 37(3):843-50. doi: 10.3892/ijmm.2016.2454

Sohail R, Abbas SR. Evaluation of amygdalin-loaded alginate-chitosan nanoparticles as biocompatible drug delivery carriers for anticancerous efficacy. Int J Biol Macromol. 2020; 153:36-45. doi: 10.1016/j.ijbiomac.2020.02.191

Chen Y, Ma J, Wang F, Hu J, Cui A, Wei Ch, et al. Amygdalin induces apoptosis in human cervical cancer cell line HeLa cells. Immunopharmacol Immunotoxicol. 2013; 35(1):43-51. doi: 10.3109/08923973.2012.738688

Qian L, Xie B, Wang Y, Qian J. Amygdalin-mediated inhibition of non-small cell lung cancer cell invasion in vitro. Int J Clin Exp Pathol. 2015; 8(5):5363-70.

Lee HM, Moon A. Amygdalin regulates apoptosis and adhesion in Hs578T triple-negative breast cancer cells. Biomol Ther. 2016; 24(1):62-6. doi: 10.4062/biomolther.2015.172

Newmark J, Brady RO, Grimley PM, Gal AE, Waller SG, Thistlethwaite JR. Amygdalin (Laetrile) and prunasin betaglucosidases: Distribution in germ-free rat and in human tumor tissue. Proc Natl Acad Sci U S A. 1981; 78(10):6513-6. doi: 10.1073/pnas.78.10.6513

El-Kholy WB, Abdel-Rahman SA, Abd El-Hady El-Safti FEN, Issa NM. Effect of vitamin B17 on experimentally induced colon cancer in adult male albino rat. Folia Morphol. 2021; 80(1):158-69. doi: 10.5603/FM.a2020.0021

Hasan, A. F., Hameed, H. M., & Alyasiri, T. (2024). Role of Vitamin B17 against Colitis Bearing Female Mice Induced Variations in Some Blood Parameters. Annual Research & Review in Biology, 27-37. doi: 10.5603/FM.a2020.0021

Lee, H. M., & Moon, A. (2016). Amygdalin regulates apoptosis and adhesion in Hs578T triple-negative breast cancer cells. Biomolecules & therapeutics, 24(1), 62. doi.org/10.4062/biomolther.2015.172

G. Edward Griffin. (1997). World Without Cancer. American Media (CA). http://books.google.com/books?id=2HRFAAAAYAAJ&dq=Understanding+Vitamin+B17+and+Its+Properties&hl=&source=gbs_api

Victor Christianto, Florentin Smarandache. On the Efficacy of High-dose Ascorbic Acid as Anticancer Treatment: A Literature Survey. Infinite Study. https://play.google.com/store/books/details?id=-1TVDwAAQBAJ&source=gbs_api.

Mosayyebi, B., Imani, M., Mohammadi, L., Akbarzadeh, A., Zarghami, N., Edalati, M., ... & Rahmati, M. (2020). An update on the toxicity of cyanogenic glycosides bioactive compounds: Possible clinical application in targeted cancer therapy. Materials Chemistry and Physics, 246, 122841. doi.org/10.1016/j.matchemphys.2020.122841

S. Meyer, Y. Goda. (2016). Complementary and Alternative Medicine in Pediatric Gastroenterology. https://www.semanticscholar.org/paper/d277ccacb1abf2ac45ac2986b8cec4fa7c3e0e8c.

Kholood K. Alnowaiser, Moataz A. Ahmed. (2022). Digital Twin: Current Research Trends and Future Directions. 48, p. 1075-1095. https://www.semanticscholar.org/paper/1cd8ad946f696b6d38ed2e9ecbae65d89a90e952.

Doaa, R.I., Abdel-Gawad., Marwa, A., Ibrahim., Hossny, A., El-Banna., Walid, H., Hassan., Fatma, I., Abo, El‐Ela. Evaluating the Therapeutic Potential of Amygdalin: Cytotoxic and Antimicrobial Properties. Tissue & Cell, (2024).;89:102443-102443. doi: 10.1016/j.tice.2024.102443.

Spanoudaki, M., Stoumpou, S., Papadopoulou, S. K., Karafyllaki, D., Solovos, E., Papadopoulos, K., ... & Giaginis, C. (2023). Amygdalin as a Promising Anticancer Agent: Molecular Mechanisms and Future Perspectives for the Development of New Nanoformulations for Its Delivery. International Journal of Molecular Sciences, 24(18), 14270. doi.org/10.3390/ijms241814270.

G, W, Newton., E, S, Schmidt., J, P, Lewis., E, Conn., R, Lawrence. 4. Amygdalin toxicity studies in rats predict chronic cyanide poisoning in humans. Western Journal of Medicine, (1981).

Charles, G., Moertel., Thomas, R., Fleming., Joseph, Rubin., Larry, K., Kvols., G, Sarna., R, Koch., V, E, Currie., Charles, W., Young., Stephen, E., Jones., J, P, Davignon. 3. A Clinical Trial of Amygdalin (Laetrile) in the Treatment of Human Cancer. The New England Journal of Medicine, (1982). doi: 10.1056/NEJM198201283060403.

Jonathan, Bromley., Brett, G.M., Hughes., David, C, S, Leong., Nicholas, A., Buckley. 2. Life-Threatening Interaction Between Complementary Medicines: Cyanide Toxicity Following Ingestion of Amygdalin and Vitamin C. Annals of Pharmacotherapy, (2005). doi: 10.1345/APH.1E634.

Alyson E. Mitchell, Piotr Bałczewski. "Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds." MDPI, 2021.

Iyanu Oduwole AA. Amygdalin-therapeutic effects and toxicity. Journal of Biotechnology and Biomedicine. 2020;3(2):39-49.