The impact of vitamin D level on serum lipids in type 2 diabetes mellitus

Zainab Subber; Hashim Hashim; Ghassan Al-Shamma

doi:10.47419/bjbabs.v2i04.47

Authors

Zainab J. Subber Department of Chemistry and Biochemistry, College of Medicine, Al-Nahrain University, Baghdad, Iraq
Hashim M. Hashim Department of Medicine, College of Medicine, Al-Nahrain University, Baghdad, Iraq
Ghassan A. Al-Shamma Department of Chemistry and Biochemistry, College of Medicine, Al-Nahrain University, Baghdad, Iraq

DOI:

https://doi.org/10.47419/bjbabs.v2i04.47

Keywords:

cholesterol, LDL-cholesterol, serum lipids, T2DM, vitamin D

Abstract

Background: Vitamin D is considered an important regulator of many metabolic processes in the body. Its deficiency was reported to associate with many pathological conditions, with contradicting reports on its role in dyslipidemia.

Objectives: To evaluate the role of vitamin D (total and/or free) in improving dyslipidemia of type 2 diabetes mellitus (T2DM).

Methods: Sixty-four patients with T2DM, and 73 apparently healthy normal subjects were enrolled in the study from March to October 2020. Their fasting blood glucose, glycated hemoglobin, HbA₁c, and serum lipids (cholesterol, its fractions and triglycerides) were measured in addition to total and free vitamin D.

Results: There was a significant negative correlation between total vitamin D and each of cholesterol and LDL-C in the diabetic group. The correlations between serum vitamin D and all other lipid parameters (HDL-C, VLDL-C and triglycerides) were non-significant in the diabetic group, while in the control groups none of serum lipids showed significant correlations with vitamin D.

Conclusions: The significant negative association of vitamin D with total cholesterol and LDLC in the diabetics reveals the important action of vitamin D in reducing the atherogenic indices, and consequent reduction in the rate of atherosclerosis and cardiovascular disease or stroke.

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