Immune-enhancing role of vitamin A-Narrative review

Authors

DOI:

https://doi.org/10.47419/bjbabs.v5i2.215

Keywords:

Vitamin A, Immune system, Inflammation, Anti- inflammatory, Viral infections

Abstract

Vitamin A has been prescribed in many cases of immunodeficiency or infection, as researchers have found that vitamin A strengthens immunity and regulates immune cells such as neutrophils, macrophages and others. On the other hand, vitamin A treatment did not reduce the length of stay in the hospital or the death-rate sepsis patients. However, vitamin A plays a positive role in the treatment of COVID-19 through regulating many significant signaling pathways. In addition, it provides protection against measles and reduces mortality, and contributes in the treatment of tuberculosis through several mechanisms. In this review we aimed to explain the role of vitamin A in enhancing body immune functions and reducing inflammation in human body.

Metrics

Metrics Loading ...

Downloads

Download data is not yet available.

References

5-Lee H, Ko G. New perspectives regarding the antiviral effect of vitamin a on norovirus using modulation of gut microbiota. Gut Microbes. 2017;8:616–636.

Huang Z, Liu Y, Qi G, Brand D, Zheng SG. Role of Vitamin A in the Immune System. J Clin Med. 2018;7(9):258. 10.3390/jcm7090258.

Iddir M, Brito A, Dingeo G, Campo SSFD, Samouda H, Frano MRL, et al. Strength- ening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis. Nutrients. 2020;12(6):1562–1562. 10.3390/nu12061562.

Stephensen CB. Vitamin A, infection, and immune function. Annu Rev Nutr . 2001;21:92–167. 10.1146/annurev.nutr.21.1.167.

Lee H, Ko G. New perspectives regarding the antiviral effect of vitamin A on norovirus using modulation of gut microbiota. Gut Microbes. 2017;8(6):616–620. 10.1080/19490976.2017.1353842.

Zhang P, Cui TT, Zhang ZH, Wang YQ. Low-dose vitamin A therapy on T lymphocyte function in neonatal pneumonia. Eur Rev Med Pharmacol Sci. 2018;22(13):4371–4374. 10.26355/eurrev20180715437.

Tian Y, Tian Q, Wu Y, Peng X, Chen Y, Li Q, et al. Vitamin A supplement after

neonatal Streptococcus pneumoniae pneumonia inhibits the progression of exper- imental asthma by altering CD4+T cell subsets. Sci Rep. 2020;10(1):4214–4214. 10.1038/s41598-020-60665-4.

Xing Y, Sheng K, Xiao X, Li J, Wei H, Liu L, et al. Vitamin A deficiency is associated with severe Mycoplasma pneumoniae pneumonia in children. The role of vitamins and minerals on the immune system Home Health Care Management & Practice. 2020;8(4):120–120. 10.21037/atm.2020.02.33.

Cherukuri L, Gewirtz G, Osea K, Tayek JA. Vitamin A treatment for severe sepsis in humans; a prospective randomized double blind placebo-controlled clinical trial. Clin Nutr ESPEN. 2019;29:49–51. 10.1016/j.clnesp.2018.10.011.

Li R, Wu K, Li Y, Liang X, Tse WKF, Yang L, et al. Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19. Aging (Albany NY). 2020;12(15):15784–15796. 10.18632/aging.103888.

Alpert PT. The Role of Vitamins and Minerals on the Immune System. Home Health Care Management & Practice. 2017;29(3). 10.1177/1084822317713300.

Cantorna MT, Snyder L, Arora J, Keane J, Sullivan MP. Vitamin A and vitamin D reg- ulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis. Crit Rev Biochem Mol Biol . 2019;54(2):184–192. 10.1080/10409238.2019.1611734.

Bahlool AZ, Grant C, Cryan SA, Keane J, c MPO. All trans retinoic acid as a host-directed immunotherapy for tuberculosis. Current Research in Immunology. 2022;22:54–72. 10.1016/j.crimmu.2022.03.003.

Halliwell B, JMC, Gutteridge. Free radicals in biology and medicine; 2015. .

Downloads

Published

01-04-2024

How to Cite

Immune-enhancing role of vitamin A-Narrative review. (2024). Baghdad Journal of Biochemistry and Applied Biological Sciences, 5(2), 87-91. https://doi.org/10.47419/bjbabs.v5i2.215

Metrics

Share