Effects of Sunflower (Aspillia Africana) Leaves on the Serum Total Protein Levels of MSG-induced Fibroids in Adult Female Wistar Rats

Chidera Obideje; Peter Eze-Steven; Kingsley Obideje

doi:10.47419/bjbabs.v5i2.274

Authors

Obideje G. Chidera Department of Biochemistry, Enugu State University of Science and Technology, Enugu State, Nigeria https://orcid.org/0009-0009-4719-7633
Eze-Steven E. Peter Department of Biochemistry, Enugu State University of Science and Technology, Enugu State, Nigeria https://orcid.org/0000-0001-9119-4290
Obideje E. Kingsley Department of Biology, Federal University Lokoja, Kogi State, Nigeria https://orcid.org/0009-0000-7424-7936

DOI:

https://doi.org/10.47419/bjbabs.v5i2.274

Keywords:

Aspillia Africana, Food addictives, Fibriods, Uterine leiomyoma, Monosodium glutamate

Abstract

Monosodium glutamate (MSG) flavor enhancing properties has projected its wide use in the food industry, yet it is taught to be linked to uterine fibroids.This study was undertaken to determine the effects of sunflower (Aspila africana) leaf extracts on serum total protein levels of MSG-induced fibroids in female wistar rats. Preparation of aqueous extract of Aspillia africana by mimicking indigenous medical practitioners. Fifteen rats were grouped randomly into three groups. Rats in group 1 severed as control and received only distilled water. Group 2 received 750 mg MSG /kg bodyweight only for 28 days, while group 3 received 750 mg MSG/Kg bodyweight for 28 days then was treated with 350 mg extract/kg bodyweight for another 28 days. Samples were collected weekly via ocular puncture and assayed for total protein. However, a day after final exposure, rats were euthanized by inhalation of chloroform. Blood was then collected by cardiac puncture and total protein levels evaluated. the result shows that MSG alone increase the total protein levels. Treatment with Aspillia africana showed no significant difference in the first three weeks (p = 0.638, p = 0.615 and p = 0.058). However, in the fourth week we observed a significant decrease (p=0.011). MSG possess degenerative effects in the female reproductive system and suggest that prolong exposure to Aspillia africana could be an effective herbal therapy for patients with fibroids without need for surgery.

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