The association between gastric bacterial infection and low level of vitamin D among patients with type 2 diabetes mellitus

Sarah T. Al-Mofarji; Haider Hussien; Nadira Mohamed; Sundus Hantoosh; Mohammed Abass; Asmaa Ali

doi:10.47419/bjbabs.v2i01.32

Authors

Sarah T. Al-Mofarji Forensic DNA Research and Training Center, Al-Nahrain University, Bagdad, Iraq
Haider K. Hussien Forensic DNA Research and Training Center, Al-Nahrain University, Baghdad, Iraq
Nadira S. Mohamed Forensic DNA Research and Training Center, Al-Nahrain University, Baghdad, Iraq
Sundus F. Hantoosh Forensic DNA Research and Training Center, Al-Nahrain University, Baghdad, Iraq
Mohammed K. Abass Forensic DNA Research and Training Center, Al-Nahrain University, Baghdad, Iraq
Asmaa Ali Forensic DNA Research and Training Center Al-Nahrain University, Baghdad, Iraq

DOI:

https://doi.org/10.47419/bjbabs.v2i01.32

Keywords:

bacterial infection, diabetes mellitus, H. pylori, vitamin D deficiency

Abstract

Objectives: The present research aimed to find an association between infection by Helicobacter pylori and vitamin D deficiency in type 2 diabetic Iraqis attending Al-Yarmouk Teaching Hospital.

Methods: According to fasting blood glucose, the samples were divided into a non-diabetic group with ten diabetic individuals and a diabetic group with thirty individuals.

Results: The anti-H. pylori (IgG) levels were 86.77±58.62 NTU/μL in diabetic patients compared with 10.12_7.40 NTU/μL in non-diabetic group. Vitamin D levels were decreased significantly in infected patients compared to non-infected subjects.

Conclusion: The H. pylori-infected patients have recorded the lowest level of vitamin D than non-infected individuals.

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References

Standards of Medical Care in Diabetes—2014. Diabetes Care. 2014;37(Suppl 1):S14–S80. Available from: https://doi.org/10.2337/dc14-S014.

TUE Physician Guidelines – Diabetes - Version 4.2 – February 2020, TUE Physician Guidelines Medical Information to Support the Decisions of TUE Committees Diabetes Mellitus.

World Health Organization. (1999). Definition, diagnosis and classification of diabetes mellitus and its complications : report of a WHO consultation. Part 1, Diagnosis and classification of diabetes mellitus. World Health Organization. ; 1999. Available from: https://apps.who.int/iris/handle/10665/66040.

Wong BC, Lam SK, Wong WM, Chen JS, Zheng TT, Feng RE, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. JAMA. 2004;291(2):187–194. Available from: https://doi.org/10.1001/jama.291.2.187.

Stolte M, Eidt S. Healing gastric MAL T lymphomas eradication H. pylori. Lancet. 1993;342:568–568. Available from: https://doi.org/10.1016/0140-6736(93)91404-a.

Tseng CH. Diabetes conveys a higher risk of gastric cancer mortality despite an age-standardised decreasing trend in the general population in Taiwan. Gut. 2011;60(6):774–779. Available from: https://dx.doi.org/10.1136/gut.2010.226522.

Holick MF. Vitamin D Deficiency. New England Journal of Medicine. 2007;357(3):266–281. Available from:https://dx.doi.org/10.1056/nejmra070553.

Bischoff-Ferrari HA, Giovannucci E, Willett WC, Dietrich T, et al. Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. Am J Clin Nutr . 2006;84(1):18–28. Available from: https://doi.org/10.1093/ajcn/84.1.18.

Holick MF. Resurrection of vitamin D deficiency and rickets. Journal of Clinical Investigation. 2006;116(8):2062–2072. Available from: https://dx.doi.org/10.1172/jci29449.

Nagpal S, Na S, Rathnachalam R. Noncalcemic actions of vitamin D receptor ligands. Endocr Rev. 2005;26(5):662–687. Available from: https://doi.org/10.1210/er.2004-0002.

Lee DM, Tajar A, Neill TO, O’Connor DB, Bartfai G, Boonen S, et al. Lower vitamin D levels are associated with depression among community-dwelling European Men. J Psychopharmacol. 2011;25(10):1320–1328. Available from: https://doi.org/10.1177/0269881110379287.

Kitson MT, Roberts SK. D-livering the message: the importance of vitamin D status in chronic liver disease. J Hepatol. 2012;57(4):897–909. Available from: https://doi.org/10.1016/j.jhep.2012.04.033.

Youssef DA, Miller CWT, El-Abbassi AM, Cutchins DC, Cutchins C, Grant WB, et al. Antimicrobial implications of vitamin D. Dermato-Endocrinology. 2011;3(4):220–229. Available from: https://dx.doi.org/10.4161/derm.3.4.15027.

Sokwala A, Shah MV, Devoni S, Youga G. Helicobacter pylori eradication: A randomised comparative trial of 7-day versus 14-day triple therapy. SAfr Med J. 2012;102((6 Pt 2)):368–371. Available from: https://doi.org/10.7196/samj.5302.

Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol. 1969;22(2):158–161. Available from: https://doi.org/10.1136/jcp.22.2.158.

Tseng CH. Diabetes, insulin use and Helicobacter pylori eradication: a retrospective cohort study. BMC Gastroenterology. 2012;12(46):1–9. Available from: https://doi.org/10.1186/1471-230X-12-46

Jeon CY, Haan MN, Cheng C, Clayton ER, Mayeda ER, Miller JW, et al. Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes. Diabetes Care. 2012;35(3):520–525. Available from: https://doi.org/10.2337/dc11-1043.

Borody T, Ren Z, Pang G, Clancy R. Impaired host immunity contributes to Helicobacter pylori eradication failure. Am J Gastroenterol. 2002;97(12):3032–3037. Available from: https://doi.org/10.1111/j.1572-0241.2002.07121.x.

de Luis DA, de la Calle H, Roy G, de Argila CM, Valdezate S, Canton R, et al. Helicobacter pylori infection and insulin-dependent diabetes mellitus. Diabetes Research and Clinical Practice. 1998;39(2):143–146. Available from:

https://dx.doi.org/10.1016/s0168-8227(97)00127-7.

Gentile S, Turco S, Oliviero B, Torella R. The role of autonomic neuropathy as a risk factor of Helicobacter pylori infection in dyspeptic patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 1998;42(1):41–48. Available from: https://doi.org/10.1016/s0168-8227(98)00088-6.

Mozaffarian D, Kamineni A, Carnethon M, Djoussé L, Mukamal KJ, Siscovick D. Lifestyle risk factors and new-onset diabetes mellitus in older adults: the cardiovascular health study. Arch Intern Med. 2009;169(8):798–807. Available from: https://doi.org/10.1001/archinternmed.2009.21.

Ojetti V, Pellicano R, Fagoonee S, Migneco A, Berrutti M, Gasbarrini A. Helicobacter pylori infection and diabetes. Minerva Med . 2010;101(2):115–119.

Burghen GA, Murrell LR, Whitington GL, Klyce MK, Burstein S. Acid peptic disease in children with type I diabetes mellitus. A complicating relationship. Am J Dis Child. 1992;146(6):718–722. Available from: https://doi.org/10.1001/archpedi.1992.02160180078021.

Jones KL, Wishart JM, Berry M, Russo A, Xia HH, Talley NJ, et al. Helicobacter pylori infection is not associated with delayed gastric emptying or upper gastrointestinal symptoms in diabetes mellitus. Dig Dis Sci. 2002;47(4):704–709. Available from: https://doi.org/10.1023/a:1014763210890.

Jeon CY, Haan MN, Cheng C, Clayton ER, Mayeda ER, Miller JW, et al. Helicobacter pylori infection is associated with an increased rate of diabetes. Diabetes Care. 2012;35(3):520–525. Available from: https://doi.org/10.2337/dc11-1043.

Weyer C, Bogardus C, Mott DM, Pratley RE, , , et al. The natural history of insulin secretory dysfunction and insulin resistance in the pathogenesis of type 2 diabetes mellitus. J Clin Invest. 1999;104(6):787–794. Available from: https://doi.org/10.1172/JCI7231.

Rahman MA, Cope MB, Sarker SA, Garvey WT, Chaudhury HS, Khaled MA. Helicobacter pylori Infection and Inflammation: Implications for Pathophysiology of Diabetes Mellitus and Coronary Heart Disease. Journal of Life Sciences. 2009;1(1):45–50. Available from: https://dx.doi.org/10.1080/09751270.2009.11885133.

Fosslien E. Mitochondrial medicine–molecular pathology of defective oxidative phosphorylation. Ann Clin Lab Sci. 2001;31(1):25–67.

Hsieh MC, Wang SSW, Hsieh YT, Kuo FC, Soon MS, and DCW. H. pylori Infection Associated with High HbA1c and Type 2 Diabetes. European Journal of Clinical Investigation. 2013;43(9):949–956. Available from: https://dx.doi.org/10.1111/eci.12124.

Lee YH, Magkos F, Mantzoros CS, Kang ES. Effects of leptin and adiponectin on pancreatic β-cell function. Metabolism. 2011;60(12):1664–1672. Available from: https://dx.doi.org/10.1016/j.metabol.2011.04.008.

Wang C, Guan Y, Yang J. Cytokines in the Progression of Pancreatic β-Cell Dysfunction. Int J Endocrinol. 2010;2010:515136–515136. Available from: https://dx.doi.org/10.1155/2010/515136.

Omori K, Mitsuhashi M, Ishiyama K, Nair I, Rawson J, Todorov I, et al. mRNA of the pro-apoptotic gene BBC3 serves as a molecular marker for TNF-α-induced islet damage in humans. Diabetologia. 2011;54(8):2056–2066. Available from: https://dx.doi.org/10.1007/s00125-011-2183-8.

Anastasios R, Goritsas C, Papamihail C, Trigidou R, Garzonis P, Ferti A. Helicobacter pylori infection in diabetic patients: prevalence and endoscopic findings. European Journal of Internal Medicine. 2002;13(6):376–379. Available from:

https://dx.doi.org/10.1016/s0953-6205(02)00094-8.

Stanciu OG, Trifan A, Sfarti C, Cojocariu C, Stanciu C. Helicobacter pylori infection in patients with diabetes mellitus. Rev Med Chir Soc Med Nat Iasi. 2003;107(1):59–65.

Rafat MN, Azeem HA, Antably A, Al-Sayed MT. Prevalence of Helicobacter pylori infection in patients with type 2 diabetes mellitus. Al-Azhar Assiut Medical Journal. 2015;13(4):93–101.

Gao T, Zhao M, Zhang C, Wang P, Zhou W, Tan S, et al. Association of Helicobacter pylori Infection with Vitamin D Deficiency in Infants and Toddlers. J Trop Med Hyg. 2020;102(3):541–546. Available from: https://dx.doi.org/10.4269/ajtmh.19-0523.

Surmeli DM, Surmeli ZG, Bahsi R, Turgut T, Oztorun HS, Atmis V, et al. Vitamin D deficiency and risk of Helicobacter pylori infection in older adults: a cross-sectional study. Aging Clinical and Experimental Research. 2019;31(7):985–991. Available from: https://dx.doi.org/10.1007/s40520-018-1039-1.

Guo L, Chen W, Zhu H, Chen Y, Wan X, Yang N, et al. Helicobacter pylori induces increased expression of the vitamin d receptor in immune responses. Helicobacter. 2014;19(1):37–47. Available from: https://dx.doi.org/10.1111/hel.12102.

Shahawy MSE, Hemida MM, Metwaly I, Shady ZM. The effect of vitamin D deficiency on eradication rates of Helicobacter pylori infection. JGH Open: An Open Access Journal of Gastroenterology and Hepatology. 2018;2(6):270–275. Available from: https://dx.doi.org/10.1002/jgh3.12081.