Di tyrosine Levels in Placental Tissue: A Gestational Age-dependent Quantitative Analysis Using Anti-Di tyrosine Antibodies

Abstract

Di tyrosine (DT), a marker of protein oxidative modification, is formed during oxidative stress, which is particularly involved in pregnancy-related pathology. However, the dynamics of DT expression at different stages of gestation remain poorly understood. This study is regarding the correlations between gestational age and the expression of DT in placental tissue. The authors studied placental tissues taken from 90 pregnant women who gave birth prematurely, at term or after term. The samples were processed by immunohistochemistry using anti-DT monoclonal antibodies. The results showed structural differences and expression of DT between groups. The assessment of DT could thus provide clinical insight into placental function and pregnancy complications related to oxidative stress.